What if we…
Semaglutide makes people regain weight
And sheet the sheets!
Semaglutide was hailed as a cure to obesity. Turns out, things can go south in many ways 😌
Weight nourishment
Semaglutide, being a GLP-1 agonist, has the following MoA:
And it’s apparently reverted after ~a year of withdrawal. Thing to notice - cardiometabolic perks reset at week 120 even while taking Semaglutide:
The scientists say it’s because there’s an inherent setting of “defended fat mass”, under which hunger activates. So, the solution is easy (no): if you get an assistance of that set point turned lower, use that time as a window of opportunity to change your habits, not a magic-rainbow-silver-bullet-pill 🤷
Refeeding vibes
The fun thing is that restricted feeding (emulated by Ozempic) is sometimes used in cattle to improve weight gain/food consumed ratio. And also in fish.
Effects are (im)permanent?
Still, the effects don’t look long-term/permanent despite being sizeable: the benefits outweigh just the diet change.
So, we’ve got:
Metabolic profile reversing during even prolonged intake
Refeeding spree resulting in weight gain
Psychological reliance on a magic pill
Massive viral addon-placebo and bandwagon effect
A recipe for weight gain disaster? Will we see people blowing up from food? I hope not (yes please sure).
Side (bottom) effects
Quoting NYT: About 30% of Wegovy users say they’ve suffered from diarrhea, while 24% have experienced constipation, according to a new article on Insider.
Flashback and rewind to Orlistat, making people literally leak feces and oil. Looks like a weight loss pill isn’t that easy to make!Another funny one is having delusional dreams of joining Kardashians… This one’s making me 100% on ‘never once Ozempic’.
Aaand losing subcutaneous water/fat, it seems - as people are having their finger sizes dwindling.
Next issue (sometime in future) will have…mental models, I swear! Even got a nice link…
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Citation
@online{kogan2024,
author = {Kogan, Zakhar},
title = {What If We...},
date = {2024-01-06},
url = {https://teleogenic.com/posts/231210-mentals},
langid = {en}
}